PLASMODIUM VIVAX AND EXOSOME RESEARCH 
(PVREX)

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BIBLIOGRAPHY

  • Barbara Baro; Katrien Deroost; Tainá Raiol; Marcelo Brito; Anne CG Almeida; Armando de Menezes-Neto; Erick Figueiredo; Aline Alencar; Rodrigo Leitão; Fernando Val; Wuelton Monteiro; Anna Oliveira; Maria del Pilar Armengol; Carmen Fernández-Becerra; Marcus Lacerda; Hernando A del Portillo. Plasmodium vivax gametocytes in the bone marrow of an acute malarial patient and changes in the erythroblast miRNA profile. PLoS Negl Trop Dis. 2017 Apr 6;11(4):e0005365

  • Martín-Jaular L, de Menezes-Neto A, Monguió-Tortajada M, Elizalde-Torrent A, Díaz-Varela M, Fernández-Becerra C, Borras FE, Montoya M, Del Portillo HA "Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution" Front Cell Dev Biol. 2016 Nov 16;4:131. eCollection 2016. 

  • Requena, Pilar; Rui, Edmilson; Padilla, Norma; Martinez-Espinosa, Flor E.; Eugenia Castellanos, Maria; Botto-Menezes, Camila; Malheiro, Adriana; Arevalo-Herrera, Myriam; Kochar, Swati; Kochar, Sanjay K.; Kochar, Dhanpat K.; Umbers, Alexandra J.; Ome-Kaius, Maria; Wangnapi, Regina; Hans, Dhiraj; Menegon, Michela; Mateo, Francesca; Sanz, Sergi; Desai, Meghna; Mayor, Alfredo; Chitnis, Chetan C.; Bardaji, Azucena; Mueller, Ivo; Rogerson, Stephen; Severini, Carlo; Fernandez-Becerra, Carmen; Menendez, Clara; del Portillo, Hernando*; Dobano, Carlota* 2016, 'Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women', Plos Neglected Tropical Diseases, 10, 10, e0005009.*equal correspondance

  • De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT. 2017 Progress in imaging methods: insights gained into Plasmodium biology. Nat Rev Microbiol. 2017 Jan;15(1):37-54. doi: 10.1038/nrmicro.2016.158. Epub 2016 Nov 28

  • De Niz, Mariana; Ullrich, Ann-Katrin; Heiber, Arlett; Soares, Alexandra Blancke; Pick, Christian; Lyck, Ruth; Keller, Derya; Kaiser, Gesine; Prado, Monica; Flemming, Sven; del Portillo, Hernando; Janse, Chris J.; Heussler, Volker; Spielmann, Tobias 2016, 'The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites', Nature Communications, 7, 11659.

  1. Vitor-Silva S, Siqueira AM, de Souza Sampaio V, Guinovart C, Reyes-Lecca RC, de Melo GC, Monteiro WM, Del Portillo HA, Alonso P, Bassat Q, Lacerda MV. Declining malaria transmission in rural Amazon: changing epidemiology and challenges to achieve elimination. Malar J. 2016 May 10;15(1):266. doi:10.1186/s12936-016-1326-2.

  1. Menegon M, Bardají A, Martínez-Espinosa F, Bôtto-Menezes C, Ome-Kaius M, Mueller I, Betuela I, Arévalo-Herrera M, Kochar S, Kochar SK, Jaju P, Hans D, Chitnis C, Padilla N, Castellanos ME, Ortiz L, Sanz S, Piqueras M, Desai M, Mayor A, Del Portillo H, Menéndez C, Severini C. Microsatellite Genotyping of Plasmodium vivax Isolates from Pregnant Women in Four Malaria Endemic Countries. PLoS One. 2016 Mar 24;11(3):e0152447. doi: 10.1371/journal.pone.0152447.
  • Martín-Jaular L, de Menezes-Neto A, Monguió-Tortajada M, Elizalde-Torrent A, Díaz-Varela M, Fernández-Becerra C, Borras FE, Montoya M, Del Portillo HA "Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution" Front Cell Dev Biol. 2016 Nov 16;4:131. eCollection 2016.

  1. Bhardwaj R, Shakri AR, Hans D, Gupta P, Fernandez-Becerra C, Del Portillo HA, Pandey G, Chitnis CE. Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development. Protein Expr Purif. 2015 Nov 12. pii: S1046-5928(15)00150-3. doi: 10.1016/j.pep.2015.06.011.

  1. Montaner-Tarbes S, Borrás FE, Montoya M, Fraile L, del Portillo HA. Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins. Vet Res. 2016 May 31;47(1):59. doi: 10.1186/s13567-016-0345-x.

  1. Fais et al., Evidence-based clinical use of nanscale extracelular vesicles in nanomedicine. ACS Nano DOI 10.1021/acsnano.5b08015.

  1. Lener T, Gimina M, et al. del Portillo HA, et al., Rhode E and Giebel B. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper, Journal of Extracellular Vesicles 2015, 4: 30087 http://dx.doi.org/10.3402/jev.v4.30087

  1. Bhardwaj R, Shakri AR, Hans D, Gupta P, Fernandez-Becerra C, Del Portillo HA, Pandey G, Chitnis CE. Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development. Protein Expr Purif. 2015 Nov 12. pii: S1046-5928(15)00150-3. doi: 10.1016/j.pep.2015.06.011.

  1. de Menezes-Neto A, Fidalgo Sáez M, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Estanyol Ullate J, et al & del Portillo HA. Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals. Journal of extracellular vesicles. 2015;4:27378.

  1. Mongui A, Pérez-Llanos FJ, Yamamoto MM, Lozano M, Zambrano MM, Del Portillo P, Fernández-Becerra C, Restrepo S, del Portillo HA*, Junca H. Development of a genetic tool for functional screening of anti-malarial bioactive extracts in metagenomic libraries. Malar J. 2015 Jun 4;14:233. doi:10.1186/s12936-015-0748-6

  1. Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém, N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracelular vesicles and their physiological functions. J Extracell Vesicles. 2015 May 14;4:27066. Doi 10.3402/jev.v4.27066.

  1. Requena P, Barrios D, Robinson LJ, Samol P, Umbers AJ, Wangnapi R, Ome-Kaius M, Rosanas-Urgell A, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo HA, Chitnis CE, Siba PM, Rogerson S, Mueller I, Bardají A, Menéndez C, Dobaño C. Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes. J Immunol. 2015 Apr 1;194(7):3275-85. doi:10.4049/jimmunol.1401038.

  1. Lozano-Ramos I, Bancu I, Oliveira-Tercero A, Armengol MP, Menezes-Neto A, Del Portillo HA, Lauzurica-Valdemoros R, Borràs FE. Size-exclusion chromatography-based enrichment of extracellular vesicles from urine samples. J Extracell Vesicles. 2015 May 28;4:27369. doi: 10.3402/jev.v4.27369.

  1. Siqueira AM, Lacerda MV, Magalhães BM, Mourão MP, Melo GC, Alexandre MA, Alecrim MG, Kochar D, Kochar S, Kochar A, Nayak K, Del Portillo HA, Guinovart C, Alonso P, Bassat Q. BMC Med. 2015 Mar 20;13:57. doi: 10.1186/s12916-015-0302-y

  1. De Niz M, Helm S, Horstmann S, Annoura T, del Portillo HA, Khan SM, Heussler VT.PLoS One. 2015 Apr 15;10(4):e0123473. doi: 10.1371/journal.pone.0123473. eCollection 2015.

  1. Kim DK, et al., del Portillo H, et al., Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2014 Nov 10. pii: btu741. [Epub ahead of print] PubMed PMID: 25388151.

  1. Montaner S, Galiano A, Trelis M, Martin-Jaular L, del Portillo HA, Bernal D, Marcilla A. The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections. Front Immunol. 2014 Sep 8;5:433. doi: 10.3389/fimmu.2014.00433. eCollection 2014. Review.

  1. Melo GC, Monteiro WM, Siqueira AM, Silva SR, Magalhães BM, Alencar AC, Kuehn A, del Portillo HA, Fernandez-Becerra C, Lacerda MV. Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon. PLoS One. 2014 Aug 26;9(8):e105922

  1. Requena P, et al., del Portillo H, et al., C, Dobaño C. Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels. J Immunol. 2014 Sep 15;193(6):2971-83. doi: 10.4049/jimmunol.1401037. Epub 2014 Aug 18. PubMed PMID: 25135831.

  1. Marcilla A, Martin-Jaular L, Trelis M, de Menezes-Neto A, Osuna A, Bernal D, Fernandez-Becerra C, Almeida IC, del Portillo HA. Extracellular vesicles in parasitic diseases. J Extracell Vesicles. 2014 Dec 22;3:25040. doi: 10.3402/jev.v3.25040. eCollection 2014.

  1. Rigat-Brugarolas LG(1), Elizalde-Torrent A, Bernabeu M, De Niz M, Martin-Jaular L, Fernandez-Becerra C, Homs-Corbera A, Samitier J, del Portillo HA. A functional microengineered model of the human splenon-on-a-chip. Lab Chip. 2014 May 21;14(10):1715-24. doi: 10.1039/c3lc51449h. Epub 2014 Mar 24.

  1. Montaner S, Galiano A, Trelis M, Martin-Jaular L, del Portillo HA, Bernal D, Marcilla A. The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections. Front Immunol. 2014 Sep 8;5:433. doi: 10.3389/fimmu.2014.00433. eCollection 2014. Review.

  1. Requena P, Campo JJ, Umbers AJ, Ome M, Wangnapi R, Barrios D, Robinson LJ, Samol P, Rosanas-Urgell A, Ubillos I, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo H, Chitnis CE, Siba PM, Bardají A, Mueller I, Rogerson S, Menéndez C, Dobaño C. 2014. Pregnancy and malaria exposure are associated with changes in the B-cell pool and in plasma eotaxin levels. J Immunol. Aug 18. pii: 1401037.

  1. Lopes SC, Albrecht L, Carvalho BO, Siqueira AM, Thomson-Luque R, Nogueira PA, Fernandez-Becerra C, Del Portillo HA, Russell BM, Rénia L, Lacerda MV, Costa FT. Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential. J Infect Dis. 2014 Jan 9. [Epubahead of print] PubMed PMID: 24415786.

  1. del Portillo HA & Chitnis CE. Talking to each other to initiate sexual differentiation. Cell. 2013;153(5): 945-7

  1. Ferrer M, Martin-Jaular L, De Niz M, Khan SM, Janse CJ, Calvo M, Heussler V, del Portillo HA. Imaging of the spleen in malaria. Parasitol Int. 2014 Feb;63(1):195-205.

  1. Martín-Jaular L, Elizalde-Torrent A, Thomson-Luque R, Ferrer M, Segovia JC,Herreros-Aviles E, Fernández-Becerra C, del Portillo HA. Reticulocyte-prone malaria parasites predominantly invade CD71hi immature cells: implications for the development of an in vitro culture for Plasmodium vivax. Malar J. 2013 Dec 1;12:434.

  1. Fernandez-Becerra C, Lelievre J, Ferrer M, Anton N, Thomson R, Peligero C,Almela MJ, Lacerda MV, Herreros E, del Portillo HA. Red blood cells derived from peripheral blood and bone marrow CD34⁺ human haematopoietic stem cells are permissive to Plasmodium parasites infection. Mem Inst Oswaldo Cruz. 2013 Sep;108(6):801-3.

  1. Versiani FG, Almeida ME, Melo GC, Versiani FO, Orlandi PP, Mariúba LA, Soares LA, Souza LP, da Silva Balieiro AA, Monteiro WM, Costa FT, del Portillo HA, Lacerda MV, Nogueira PA. High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms. Malar J. 2013 Aug 27;12:294.

  1. Lopez FJ, Bernabeu M, Fernandez-Becerra C and del Portillo HA. Computational approaches redefine the subtelomeric vir multigene superfamily of Plasmodium vivax. BMC Genomics. 2013 Jan 16;14:8

  1. Siquerira-Machado A, Lopes Magalhães BA, Cardoso-Melo G, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C, Ordi J, Martinez A, Lacerda MVG and del Portillo HA. Spleen rupture in a case of untreated Plasmodium vivax infection. PLoS Negl Trop Dis. 2012;6(12):e1934.

  1. Sanchez CP, Pfahler J, del Portillo HA, Lanzer M. Transient transfection of Plasmodium vivax blood-stage parasites. Methods Mol Biol. 2013;923:151-9.

  1. Bernabeu M, Gomez-Perez GP, Sissoko S, Niambélé MB, Haibala AA, Sanz A, Théra MA, Fernandez-Becerra C, Traoré K, Bassat Q, del Portillo HA and Ogobara Doumbo. Plasmodium vivax malaria in Mali: a study from three different regions. Malar J. 2012 Dec 5;11(1):405.

  1. Mayor A, Bardají A, Felger I, King C, Cisteró P, Dobaño C, del Portillo HA, Mueller I, Ordi J, Menéndez C, Rogerson S. Placental infection with Plasmodium vivax: a histopathological and molecular study". J Infect Dis. 2012 Dec;206(12):1904-10.

  1. Betuela I, Rosanas-Urgell A, Kiniboro B, Stanisic DI, Samol L, de Lazzari E, del Portillo HA, Siba P, Alonso PL, Bassat Q, MuellerI. Relapses contribute significantly to the risk of P. vivax infection and disease in Papua New Guinean children 1-5 years of age. J Infect Dis. 2012 Dec;206(11):1771-80.

  1. Lacerda MVG, Fragoso SCP, Alecrim MG, Alexandre MAA, Magalhães BML, Siqueira AM, Ferreira LCL, Araújo JR, Mourão MPG, Ferrer M, Castillo P, Martin-Jaular L, Fernandez-Becerra C,Portillo HA,Ordi J, Alonso P, and Bassat Q. Postmortem Characterization of Patients with Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent does this Parasite Kill? Clin Infect Dis. 2012 Oct;55(8):e67-74.

  1. Rosanas-Urgell A, Martin-Jaular L, Ricarte-Filho J, Ferrer M, Kalko S, Kimura E, del Portillo HA. Expression of Non-TLR Pattern Recognition Receptors in the Spleen of Balb/c Mice Infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS. Memorias Instituto Osvaldo Cruz. 2012 May;107(3):410-5.

  1. del Portillo HA, Ferrer M, Brugat T, Martin-Jaular L, Langhorne J, Lacerda MV. The role of the spleen in malaria. Cell Microbiol. 2012 Mar;14(3):343-55.

  1. Bernabeu M, Lopez FJ, Ferrer M, Martin-Jaular L, Razaname A, Corradin G, Maier AG, Del Portillo HA, Fernandez-Becerra C. 2011. Functional analysis of Plasmodium vivax Vir proteins reveals different sub-cellular localizations and cytoadherence to the ICAM1 endothelial receptor. Cell Microbiol. 2012 Mar;14(3):386-400.

  1. Ferrer M, Martin-Jaular L, Calvo M, del Portillo HA. Intravital microscopy of the spleen: quantitative analysis of parasite mobility and blood flow. J Vis Exp. 2012 Jan 14;(59). pii: 3609. doi: 10.3791/3609.

  1. Martin-Jaular L, Nakayasu ES, Ferrer M, Almeida IC, del Portillo HA. Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections. PLoS One. 2011;6(10):e26588. Epub 2011 Oct 26.

  1. Rui E, Fernandez-Becerra C, Takeo S, Tsuboi T and del Portillo HA. 2011. Comparison of immunogenicity among vivax malaria proteins expressed in small-scale cell-free systems by suspension array assays. Malar J 2011; 10:192.

  1. Costa FTM, Lopes SCP, Ferrer M, Leite JA, Martin-Jaular L, Nogueira PA, Mourão MPG, Bernabeu M, Fernandez-Becerra C, Lacerda MVG, del Portillo HA. 2011. On cytoadhesion of Plasmodium vivax: raison d´être? Mem Inst Osw Cruz 106(Suppl. I): 79-84.

  1. malERA Consultative Group on Vaccines (del Portillo HA), Alonso PL, Ballou R, Brown G, Chitnis C, Loucq C, Moorthy V, Saul A, Wirth D. A research agenda for malaria eradication: vaccines. PLoS Med. 2011 Jan 25;8(1):e1000398.

  1. Martin-Jaular L, Ferrer M, Calvo M, Rosanas-Urgell A, Kalko S, Graewe S, Soria G, Cortadellas N, Ordi J, Planas A, Burns J, Heussler V, Del Portillo HA. 2011. Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape. Cell Microbiol. 13(1) 109-122.

  1. Anna Rosanas-Urgell, Dania Mueller, Inoni Betuela, Céline Barnadas, Jonah Iga, Peter A. Zimmerman, Hernando A. del Portillo, Ivo Mueller, Ingrid Felger. 2010. Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea. Malaria J 9(1) 361.

  1. Bruna O. Carvalho, Stefanie C. P. Lopes, Paulo A. Nogueira , Patricia P. Orlandi , Daniel Y. Bargieri , Yara C. Blanco , Ronei Mamoni ,Juliana A. Leite, Mauricio M. Rodrigues, Irene S. Soares, Tatiane R. Oliveira, Gerhard Wunderlich, Marcus V. G. Lacerda, Hernando A. del Portillo, Maria O. G. Araújo, Bruce Russell, Rossarin Suwanarusk, Georges Snounou, Laurent Rénia and Fabio T. M. Costa. 2010. On cytoadhesion of Plasmodium vivax-infected erythrocytes. J Inf Dis, 202:638-47.

  1. Carmen Fernandez-Becerra, Sergi Sanz, Marina Brucet, Danielle I Stanisic, Fabiana P Alves, Erney P. Camargo, Pedro Alonso, Ivo Mueller, Hernando A del Portillo. 2010. Naturally acquired humoral immune responses against the N- and C-termini of the P. vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay. Malaria Journal, 9:29-37.

  1. Ivo Mueller, Mary R. Galinski, J. Kevin Baird, Jane M. Carlton, Dhanpat K. Kochar, Pedro L. Alonso, and Hernando A. del Portillo. 2009. Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. Lancet Infectious Diseases, 9(9): 555-566.

  1. Pamela Orjuela-Sánchez, Franklin Simões de Santana Filho, Ariane Machado-Lima, Yonne Francis Chehuan, Mônica Regina Farias Costa, Maria das Graças Costa Alecrim, and Hernando A. del Portillo. 2009. Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine resistant isolates from the Brazilian Amazon region. Antimicrobial Agents and Chemotherapy, 53(8):3561-3564

  1. Carmen Fernández-Becerra, Maria Jesús Pinazo, Ana González, Pedro L. Alonso, Hernando A. del Portillo, and Joaquim Gascón J. 2009. First clinical case of severe Plasmodium vivax malaria in Spain and increased expression levels of the multidrug resistance genes pvcrt-o and pvmdr1. Malaria Journal, 8:55

  1. Carmen Fernandez-Becerra, Márcio M. Yamamoto, Ricardo Z.N. Vêncio, Marcus Lacerda, Rosanas-Urgell A and Hernando A del Portillo. 2009. Plasmodium vivax and the importance of the subtelomeric multigene family. Trends Parasitology, 25:44-51

  1. Carlton J, et al., del Portillo HA, et al. and Fraser-Liggett CM. 2008. Comparative genomics of the neglected human parasite Plasmodium vivax. Nature, 455: 757-763

  1. Ariane M Lima, Hernando A del Portillo, Alan M Durham. 2008. Computational Methods in non-coding RNA Research. Journal of Mathematical Biology, 56(1-2):15-49

  1. Mauro F Azevedo and Hernando A del Portillo. 2007. Promoter regions of Plasmodium vivax are poorly recognized by P. falciparum. Malaria Journal 6:20.

  2. Juliana Martha Sá, Marcio M. Yamamoto, Carmen Fernandez-Becerra, Mauro Ferreira de Azevedo, Janni Papakrivos, Bronwen Naudé, Thomas E. Wellems and Hernando A. del Portillo. 2006. Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum. Mol. Biochem. Parasitol 150(2):219-228

  1. Tatiane Rodrigues Oliveira, Carmen Fernandez-Becerra, Maria Carolina S Jimenez, Hernando A del Portillo & Irene S Soares. 2006. Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil. Malaria Journal 2006, 5:83     doi:10.1186/1475-2875-5-83.

  1. Albretch L, Merino EF, Hoffmann EHE, Ferreira UM, Ferreira de Mattos RG, Osakabe AL, Dalla RC, Ramharter M, Durham AM, Ferreira JE, del Portillo HA, Wunderlich G. 2006. Extense variant gene family repertoire overlap in Western Amazonian Plasmodium falciparum Isolates Mol Biochem. Parasitol. 150(2):157-65.

  1. Erika H.E. Hoffmann, Rosely S. Malafronte, Sandra L. Moraes-Ávila, Ana Lúcia Osakabe, Gerhard Wunderlich, Alan M. Durham, Paulo Eduardo M. Ribolla, Hernando A. del Portillo, Marcelo U. Ferreira. 2006. Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of . Gene 376:224-30.

  1. Emilio F. Merino, Carmen Fernandez-Becerra C, Alan M. Durham, João E. Ferreira, Vanessa F. Tumilasci, Joana d`Arc-Neves, Monica da Silva-Nunes, Marcelo U. Ferreira, Thilan Wickramarachchi, Preethi Udagama-Randeniy, Shiroma M. Handunnetti and Hernando A. del Portillo. 2006. Multi-character population study of the vir superfamily of Plasmodium vivax, a major human malaria parasite. Mol Biochem. Parasitol. 149:10-6.

  1. Paulo Afonso Nogueira, Fabiana Piovesan Alves, Carmen Fernandez-Becerra, Oliver Pein, Neida Rodrigues Santos, Luiz Hildebrando Pereira da Silva, Erney Plessman Camargo & Hernando A. del Portillo. 2006. Plasmodium vivax malaria: reduced risk of infection and clinical protection are associated with antibodies against the N-terminus but not the C-terminus of PvMSP1. Inf and Imm, 74: 2726-2733.

  1. Carmen Fernandez-Becerra, Oliver Pein, Tatiane Rodrigues de Oliveira, Marcio Massao Yamamoto, Antonio Carlos Cassola, Claudia Rocha, Irene S. Soares, Carlos Alberto de Bragança Pereira and Hernando A del Portillo. (2005) Variant proteins of Plasmodium vivax are not clonally expressed in natural infections. Mol Microbiol, 58, 648-658.

  1. Llinas M. and del Portillo HA. (2005) Mining the malaria transcriptone of the intraerythrocytic developmental cycle. Trends in Parasitology 21, 350-352.

  1. Kirchgatter K and del Portillo HA. 2005. Clinical and molecular aspects of severe malaria. Anais da Academia Brasileira de Ciências 77(3): 1-21.

  1. Juliana Martha Sá, Takashi Nomura, Joana d’Arc Neves, J. Kevin Baird, Thomas E. Wellems & Hernando A. del Portillo. 2005. Allele variants of the Plasmodium vivax mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua and monkey-adapted strains. Exp. Parasitol. 109: 256-259.

  1. Hernando A. del Portillo, Michael Lanzer, Fidel Zavala, Sergio Rodriguez-Malaga and Carmen Fernandez-Becerra. 2004. Variant genes and the Spleen in Plasmodium vivax Malaria. Int. J. Parasitol. (Invited Review) 34, 1547-1554.

  1. Cassera MB, Gozzo FC, D’Alexandri FL., Merino EF, del Portillo HA, Peres VJ, Almeida I.C, Eberlin MN, Wunderlich G, Wiesner J, Jomaa H, Kimura EA. & Katzin AM. 2004. The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. J. Biol. Chem., 279: 51749-59.

  1. Carnevale S, Velázquez JN, del Portillo H, Labbé JH, Cabrera MG, Ferella M, Andersson B, Guarnera EA and Angel SO. 2004. Identification and characterization of an interspersedrepetitive DNA fragment in Plasmodium vivax with potential use for specific parasite detection. Exp Parasitol 108:81-88.

  1. Chris J. Janse, Alireza Haghparast, Márcia A. Sperança, Jai Ramesar, Hans Kroeze, Hernando A. del Portillo, Andrew P. Waters. 2003. Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase. Mol Microbiol., 50(5) 1539-1552.

  1. Merino EF, Fernandez-Becerra C, Madeira AMBN, Machado AL, Durham A, Gruber A, Hall N & del Portillo HA. 2003. Pilot survey of expressed sequence tags (ESTs) from the asexual blood stages of Plasmodium vivax in human patients. Malaria Journal. 2:21-28.

  1. Fernandez-Becerra C, de Azevedo MF, Yamamoto MM & del Portillo HA. 2003. Plasmodium falciparum: new vector with bidirectional promoter acttivity to stably express transgenes. Exp. Parasitol. 103: 88-91.

  1. Karin Kirchgatter and Hernando A. del Portillo. 2002. Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1a sequences lacking cysteine residues. Molecular Medicine, 8(1): 16-23.

  1. del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez, C., Schneider N, Villalobos JM, Rajandream M-A, Harris D, L. Pereira da Silva, Barrel B & Lanzer M. 2001. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature, 410: 839-842.

  1. Takashi Nomura, Jane M-R. Carlton, J. Kevin Baird, Hernando A. Del Portillo, David J. Fryauff, Dharmendar Rathore, David A. Fidock, Xin-zhuan Su, William E. Collins, Thomas F. McCutchan, John C. Wootton and Thomas E. Wellems. 2001. Evidence for different mechanisms of chloroquine resistance in two Plasmodium species that cause human malaria. J. Inf. Dis., 183: 1653 – 1661.

  1. Sperança, MA, Vinkenoog R, Ocampos M, Fischer K, Janse CJ, Waters AP and del Portillo HA. 2001. Overexpression of the Plasmodium vivax crk2 gene and novel malarial/yeast cdc2-chimeras induce mitotic catastrophe. Exp. Parasitol., 97: 119-128.

  1. Wunderlich G, Moura IC and del Portillo HA. 2000. Genetic Immunization of Balb/C mice with a plasmid coding for a hybrid Merozoite Surface Protein 1/Hepatitis B surface-fusion protein partially protects mice against lethal P. chabaudi chabaudi PC1 Infection. Inf. Imm. 68: 5839-5845.

  1. Wunderlich, G. and del Portillo, H.A. 2000. Biochemical and immunological properties of a hybrid viral particle expressing the C-terminal region of the merozoite surface protein of Plasmodium vivax. Mol. Med. 6(3): 238-245.

  1. Kirchgatter, K., Mosbach, R. and del Portillo, H.A. 2000. Plasmodium falciparum: DBL-1 var sequence analysis in field isolates from Central Brazil. Exp. Parasitol., 95: 154-157.

  1. Oliveira, CI., Wunderlich, G., Levitus, GL., Soares IS., Rodrigues MM., Tsuji, M., and del Portillo, H.A. 1999. Antigenic properties of the Merozoite Surface Protein 1 gene of Plasmodium vivax. Vaccine, 17: 2959-2968.

  1. Soares IS, Da Cunha MG, Silva MN, Souza JM, del Portillo H.A, and Rodrigues MM. 1999. Longevity of naturally acquired antibody responses to the N- and C-terminal regions of Plasmodium vivax Merozoite Surface Protein1. Am. J. Trop. Med. Hyg., 60: 357-363.

  1. Kirchgatter, K., and del Portillo, H.A. 1998. Molecular analysis of Plasmodium vivax relapses using the MSP1 molecule as a genetic marker. J. Inf. Dis. 177: 511-515.

  2. Vinkenoog, R., Aparecida, MS., van Breemen, O., Ramesar, J., Williamson, D.H., Ross-MacDonald, PB., Thomas, AW., Janse, CJ., del Portillo, H.A., and Waters, AP. 1998. Malaria parasites contain two identical copies of an elongation factor 1 alpha gene. Mol. Biochem. Parasitol. 94: 1-12.

  3. Vinkenoog, R., Aparecida, MS., Ramesar, J., Thomas. AW., del Portillo, H.A., Janse, CJ., and Waters, AP. 1998. Characterization of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei. Mol. Biochem. Parasitol. 95: 229-240.

  1. Camargo, AA., Fisher, K., Lanzer, M. and del Portillo, H.A. 1997. Construction of a genomic library of Plasmodium vivax in Yeast Artificial Chromosomes. Genomics, .42: 467-473.

  1. Soares I, Levitus G, del Portillo H.A and Rodrigues MM. 1997. Characterization of naturally acquired cellular and human immune reponses against the MSP1 protein of Plasmodium vivax. Infection and Immunity, 65: 1606 - 1614.

  1. Levitus, G., Mertens, F., Kirchgatter, K, Oliveira, SG and del Portillo, H.A. 1997. Plasmodium vivax: epitope mapping of Mabs against the N-terminal region of the MSP1 molecule. Behring Institute Res. Comm. 99:107-111.

  1. Moreira, M.E.C., del Portillo, H.A., Balanco, M., Milder, R.V. and Barcinski, M. 1996. Heat shock induction of apoptosis in a unicellular organism. J. Cell. Physiol., 167: 305-313.

  1. Waters, A.P., Wirth, D.F., Wellems, T.E. and del Portillo, H.A. 1996. Transfection of Malaria. Parasitology Today, 12: 129-132.

  1. Vinkenoog, R., Veldhuisen, B., Sperança, M.A., del Portillo, H.A., Janse, C. and Waters, A. 1995. Comparison of introns in a cdc2-homologous gene within a number of Plasmodium species. Mol. Biochem. Parasitol., 71: 233-241.

  1. Levitus, G. and del Portillo, H.A. 1994. Advances toward the development of an asexual blood-stage MSP-1 vaccine of Plasmodium vivax. Mem. Inst. Oswaldo Cruz (Special Issue on the Proceedings of the CEC/Latin American Malaria Conference), 89 (II): 81-84.

  1. Janse, C., Camargo, A.A., del Portillo, H.A., Herrera, S., Kumlien, S., Mons, B. and Water, A.P. 1994. Removal of leukocytes from Plasmodium vivax-infected blood. Annals of Tropical Medicine and Parasitology, 88(2): 213-216.

  1. Mancilla, L.I., Levitus, G., Kirchgatter, K., Mertens, F., Herrera, S. and del Portillo H.A. 1994. Plasmodium vivax: Dimorphic DNA sequences from the MSP-1 gene codes for regions that are immunogenic in natural infections. Exp. Parasitol., 79: 148-158.

  1. Levitus, G., Mertens, F., Sperança, M.A., Camargo, L.M.A., Ferreira, M.U. and del Portillo, H.A. 1994. Characterization of the naturally acquired IgG immune responses against the Merozoite Surface Protein 1 of Plasmodium vivax. Am. J. Trop. Med. Hyg., 51(1): 68-76.

  1. Mertens, F., Levitus, G., Ferreira, M.U., Camargo, L.M.A., Dutra, A.P. and del Portillo, H.A. 1993. Longitudinal study of naturally acquired humoral immune responses against the Merozoite Surface protein 1 of in patients from Rondônia, Brazil. Am. J. Trop. Med. Hyg. 49: 383-392.

  1. del Portillo, H.A., Barreiro, L., Camargo, A.A. and Levitt, A. 1993. Amplification of single copy genes of Plasmodium vivax from two drops of peripheral blood of infected patients. J. Protozool. Res. 3: 20-24.

  1. del Portillo, H.A., Levitus, G., Camargo, L.M.A., Ferreira, M.U. and Mertens, F. 1992. Human IgG reponses against the N-terminal region of the merozoite surface protein 1 of Plasmodium vivax. Mem. Inst. Oswaldo Cruz (Special issue on the Proccedings of the IV International Congress on Malaria and Babesiosis) 87(3): 77-84.

  1. Porto, M., Ferreira, M.U., Camargo, L.M.A. and del Portillo, H.A. 1992. A new allele of the Merozite surface protein 1 gene of Plasmodium vivax. Mol. Biochem. Parasitol. 54: 121-124.

  1. del Portillo, H.A., Longacre, S., Khouri, E. and David, P.H. 1991. Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc. Natl. Acad. Sci. USA. 88: 4030-4034.

  1. del Portillo, H.A., Gysin, J., Mattei, D.M., Khouri, E., Udagama, P.V., Mendis, K.N. and David, P.H. 1988. Plasmodium vivax: cloning and expression of a major blood-stage surface antigen. Exp. Parasitol. 63: 346-353.

  1. David, P.H., del Portillo, H.A. and Mendis, K.N. 1988. Plasmodium vivax: parasite biology defines potential targets for vaccine development. Biol. Cell. 64: 251-260.

  1. del Portillo, H.A. 1988. Perspectivas para una nueva vacuna sintética contra la malaria. Interciencia 13: 262-263.

  1. del Portillo, H.A., Nussenzweig, R.S. and Enea, V. 1987. Circumsporozoite gene of a Plasmodium falciparum strain from Thailand. Mol. Biochem. Parasitol. 24: 289-294.

  1. Yoshida, N., del Portillo, H.A., di Santi, S.M., Nussenzweig, R.S. and Enea, V. 1987. Plasmodium falciparum: epidemiological studies on the circumsporozoite gene. Exp. Parasitol. 64: 510-513.

  1. del Portillo, H.A., Schmidt, G.W. and Damian, R.T. 1987. Immunochemical analysis of baboon (Papio cynocephalus) IgG subclasses. Vet. Immunol. Immunopathol. 16: 201-214.

  1. del Portillo, H.A. and Damian, R.T. 1986. Experimental Schistosoma mansoni infection in a small New World monkey, the saddle-back tamarin (Saguinus fuscicollis). Am. J. Trop. Med. Hyg. 35: 515-522.

  1. del Portillo, H.A. and Dimock, R.V. 1982. Specificity of the host-induced negative phototaxis of the symbiotic water-mite Unionicola formosa. Biol. Bull. 162: 163-170.

  1. del Portillo, H.A., Cufino, F. and Ramirez, J.M. 1980. Aotus trivirgatus del Catatumbo-Colombia (cariotipo). Revista de la Universidad de La Salle 2: 49-55.